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Comparison of Formal Thought Disorder in the Acute Episode of Schizophrenia and Manic Episode of Bipolar Affective Disorder: Study included a total of 34 schizophrenia (SCH) patients not meeting the standardized remission criteria and 20 patients in bipolar affective disorder (BP) manic episode. The patients completed the Positive and Negative Syndrome Scale, the Clinical Global Impression Scale (CGI), the Young Mania Rating Scale, the Hamilton Depression Rating Scale and the Thought and Language Disorder Scale (TALD) in order to assess formal thought disorder (FTD). The association of FTD with the diagnoses was analyzed by a logistic regression model including the TALD factors and the SCH and BP groups.
Statistically significant differences were not determined between the demographic features, the CGI scores and the TALD objective positive factor scores of the SCH and BP groups. The objective negative and subjective negative factors were higher in SCH group and the subjective positive factor were significantly higher in BP group. In the logistic regression model, the TALD subjective positive factor was associated with BP diagnosis, and the objective negative factor was associated with SCH diagnosis. In the BP group, the TALD total score correlated positively with the manic episode severity, and the scores on the subjective negative and subjective positive factors correlated negatively with disease duration. The study results show that FTD is common to the acute episodes of both SCH and BP and that assessment of the subjective positive FTD symptoms and objective negative FTD symptoms may be useful to differentiate the acute episode of SCH from the BP manic episode.